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In a chronic-acute combined stress (CACS) paradigm used to simulate irritable bowel syndrome (IBS) associated with behavioral complications such as anxiety, administration of RES before CACS for 3 weeks significantly reversed CACS-induced depression and anxiety-like behaviors and intestinal dysfunction in mice

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In summary, in Example 1 described above, significant increases in tGSH and GSH were noted in the Immunocal® treated group, and significant improvements were also seen in Vineland, CARS, SCQ, and ADI-R totals in the Immunocal® treated group