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mthfr gene and glutathione Polymorphisms: A Single Gene with Wide-Ranging Clinical Implications—A Review Type:25g
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Such an increased lysosomal pH could be a direct consequence of copper accumulation, as the vacuolar H + -ATPase, responsible for lysosomal acidification, can be blocked in vitro by the formation of intramolecular disulfide bonds, e.g., by copper induced thiol-oxidative protein damage [154]
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