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The complementary MOAs of amylin-analog and GLP-1 receptor agonists appear to be a promising combination therapy with greater weight loss than any other currently approved AOM and the potential to further close the gap with bariatric surgery outcomes.” 4 REDEFINE 1 Trial Design and Patient Profile The 68-week, multicenter, double-blind, placebo- and active-controlled REDEFINE 1 trial, enrolled 3417 adult patients without diabetes and who have a body-mass index (BMI) of 30 or more or a BMI of 27 or more with at least one obesity-related complication