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3.1 Roles of ROS and NO in the pathophysiology of human diseases 3.1.1 Oxidative stress, ROS, inflammatory markers and different types of cancer: Connecting the dots 3.1.1.1 Role in carcinogenesis The mechanism of carcinogenesis is divided into different stages: progression, promotion, and initiation
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It is noteworthy to mention here with respect to certain medications like non-steroidal anti-inflammatory drugs (NSAIDs) such as indomethacin or ibuprofen, perturbs the afferent arteriole blood flow to the nephron via inhibition of the vasodilating PGI 2 cyclooxygenase (COX) product ( Alterations in vasoactive substances or abnormal ion channel function may play a role in the development of hypertension in ESRD (Martinez-Maldonado, 1998)
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