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Using the Seahorse metabolic functional assay, we determined that enriched CAR T cells from LTR have significantly higher basal and maximal oxidative phosphorylation (OXPHOS) without substantial change in basal glycolysis compared to those from STR (Fig
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At the molecular level, CDK5 upregulates oncogenic ERK5-AP-1 (activating protein-1) signaling in CRC cells
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