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2.2 Endometriosis Endometriosis is a chronic disease characterized by the ectopic growth of endometrial-like tissue outside the uterine cavity, resulting in inflammatory, hormone dependent, immunological, systemic, and heterogeneous pathophysiological features, predominantly affecting reproductive-aged women (Sinaii et al., 2008)

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Group constants are special micro constants when the rest of the groups in the molecule are far enough apart, and their protonation does not affect the basicity of the group [80]