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Frontiers | The Activation of Endothelial Cells Relies on a Ferroptosis-Like Mechanism: Novel Perspectives in Management of Angiogenesis and Cancer Therapy

These two parameters have proved to be crucial in determining the success and effectiveness of PBM in various studies

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Although new technologies such as co-culture systems, patient-derived primary cells, and organoids attempt to reconstruct cellular interactions, the complete simulation of critical physiological factors in vivo —including tissue hierarchical structure, biomechanical environment, nutrient gradients, and neurovascular regulation—remains a core scientific and technical challenge in current in vitro research