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Friedmann AngeliJSchneiderMPronethBTyurinaYTyurinVHammondVet alInactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

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In order to investigate the effects of SAG on hepatic damage, mice were intraperitoneally injected with CCl4 1 mL/kg twice a week for 8 consecutive weeks to induce liver fibrosis and were treated orally for 8 weeks with SAG (30 mg/kg) dissolved in saline (Figure 2)