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Many therapeutic mAbs directed against IGF-1R have been developed, and encouraging preclinical activity has been observed with ganitumab [53], figitumumab [54], dalotuzumab [67], R-1507 [55], robatumumab [56], and istiratumab, a tetravalent bispecific mAb that inhibits both IGF-1R and ErbB3 [57], in a wide range of tumor models [1]

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