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ROS serves as an upstream signaling molecule for JNK, functioning as a secondary messenger within the JNK signaling pathway ( 3.3 Nrf2 pathway Nrf2 assumes a critical role by activating the body's antioxidant response through binding to antioxidant response elements (ARE) in the promoter regions of numerous genes responsible for cellular protection ( Keap1 functions as an interacting partner of Nrf2, binding with Nrf2 to facilitate its degradation and exert a negative regulatory influence on Nrf2 activity
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