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Behavioral assessments showed that mice in the EAS treatment group (45.5 mg/kg/day, administered for 20 days) exhibited significant improvements in motor function, including prolonged latency in the rotarod test and enhanced scores in the suspension test
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Furthermore, dual-targeting nanovaccines composed of heterocyclic lipids (A18) and polyesters (BR647) simultaneously incorporating oligomeric hyaluronic acid and DMG-PEG2000-mannose and encapsulating STAT3 siRNA and model antigens, can activate the STING pathway and promote the polarization of tumor-associated neutrophils from N2 to N1 (115)
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