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With regard to the role of Insulin/IGF system in metabolic reprogramming in CRC, studies on HCT116 cells showed an inducing effect of IGF-1 on the increase in HIF-1α synthesis, the main regulator of the Warburg effect and the well-known VEGF gene transactivator
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A model of the ternary complex was built into density using prior structures of DDB1 (Protein Data Bank (PDB): 5FQD) and AlphaFold2 models of DCAF11 and DDX18
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