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Increased functional connectivity could be inferred from the augmented spinogenesis, the colocalization of synaptic markers on the newly formed dendritic spines, and a concomitant enhancement of miniature excitatory postsynaptic currents

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Clinical experience suggests good tolerability, with: Mild injection site reactions Occasional digestive changes (particularly with oral administration) Rarely reported headache Important Safety Considerations Both peptides should be prescribed and monitored by qualified medical providers Quality of peptide sourcing matters — compounding pharmacies should be licensed and regulated Lab monitoring (particularly IGF-1 for sermorelin) is essential for ongoing safety Contraindications (active malignancies, certain medical conditions) must be evaluated Medical Disclaimer Sermorelin was previously FDA-approved for diagnostic use (Geref Diagnostic) and is currently prescribed off-label through compounding pharmacies