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The excited sensitizer forms an encounter complex with 3 O 2 , allowing the sensitizer to relax to a singlet state, generating reactive 1 O 2 at the same time, in an overall spin-conserved process.(38) The dark reaction involves a chemical reaction, such as thermal decomposition of peroxynitrite [ONOO −
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Other NRF2 target genes (GPX4, GSH, and NADPH syntheses) and epigenetic regulators responsible for regulating lipid hydroperoxides are also involved in ferroptosis [[58], [59], [60]]
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